Monday, February 16, 2009

Analysis of children with severe sepsis

Sepsis is a major cause of child deaths one. 2004 International Sepsis diagnosis and treatment guidelines for sepsis to rescue one of the tasks are to raise awareness of sepsis and improve the prognosis of severe sepsis. The United States each year has more than 42,000 cases of children with severe sepsis.
General Assembly 2002 International Sepsis Sepsis children first identified the virus, septic shock and other related concepts, emphasis on children's awareness of severe sepsis. Epidemiological data show that children in the United States severe sepsis mortality rate 10.3%, basic disease fatality rate has risen to 12.8%, hematologic malignancies of children with severe sepsis and septic shock when the fatality rate as high as 69%.
Severe sepsis basic common diseases, infant to congenital heart disease, chronic lung disease and premature growth retardation mainly children and adolescents with blood diseases mainly of Cancer. Congenital malformations not only lead to a major cause of infant mortality, and is also a risk factor for severe infection. Malnourished children are susceptible sepsis.
Pulmonary sepsis are the most common primary site of infection, followed by intra-abdominal infections. Cancer children followed a common site of infection are the lungs, arterio-venous indwelling catheter-related bloodstream infections, skin and soft tissue infections. Bacterial sepsis are the most important pathogen of children. This arterio-venous indwelling catheter and broad-spectrum antibiotic closely related to the application.
PCIS lower and higher PRISM not only reflects the PICU in children with systemic multiple organ system damage damaged and can be prompted to disease prognosis. 2008 sepsis guidelines recommend the diagnosis severe sepsis 1h after the application of antibiotics can improve the prognosis of patients, 6h goal of treatment can reduce hospital mortality 28d.
In summary, children with severe sepsis mortality rate high, are a serious threat to the lives of children, one critically ill patients. Some clinical signs, including decreased platelet count, serum lactic acid increased the concentration of shock and MODS are the risk factors leading to death. Improve the extent of disease in critical early awareness and intervention to take active measures to improve the prognosis of children with severe sepsis and to reduce the mortality of the key.

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